(066) Low Serum Testosterone and Mortality After Solid Organ Transplantation: A Multi-institutional Analysis of the TriNetX Research Network

Abstract Introduction Low serum testosterone has previously been suggested as a predisposing factor contributing to mortality after solid organ transplant. Previous studies on this topic stem from single-center retrospective series. Objective To determine the impact of low risk for transplantation using TriNetX, large de-identified, multi-institutional database. Methods Data source, Patient Selection, and Outcomes We compiled all clinical data TriNetX research network, health network (with waiver Western IRB) that provides de-identified information 58 care organizations, over 80 million patients located within United States. selected male (age ≥ 18) with history lung, kidney, liver, heart, or pancreas Cases were included if was drawn one year before excluded therapy. categorized into two groups, based levels. defined having (Low T) by following criteria: total < 300 (ng/Dl), diagnosis hypogonadism (ICD-10: E29.1). For patients, characteristics/demographics including comorbidities, laboratory findings, medication use compared descriptive statistics. Our outcomes interest at 1-year, 3-year, any time. Statistical analyses evaluated differences in baseline characteristics between levels (Normal T, T), chi-square Fisher’s exact test categorical an independent t-test continuous data. address potential confounders could bias our results, we used propensity score weighted regression matched age, race/ethnicity, comorbid conditions, multiple transplant status, immunosuppressant use. A Cox model probability mortality. All performed R version 4.0.4. Results 1,762 men identified transplants. Of these, 792 met criteria (Table 1). correlated higher rates 1 year, 3 years, all-time (Figure Conclusions time is up years transplantation. Future work will focus individual transplants whether modifying therapy changes outcomes. Disclosure No